Helping the smallest humans survive some of the biggest challenges
Why is it a problem?
Why is it a problem?
What is preterm birth?
The World Health Organization (WHO) defines preterm
babies as those born alive before 37 weeks of pregnancy are
completed. But there are sub-categories of preterm birth,
based on gestational age:
• extremely preterm (less than 28 weeks)
• very preterm (28 weeks to less than 32 weeks)
• moderate to late preterm (32 weeks to less than 37 weeks).
At Cure Kids, although there is a natural overlap with areas of
health research, our preterm researchers are often focused
on extremely preterm babies, i.e. those between 23 and 27
weeks gestation (i.e. less than 28 weeks)
Why does preterm birth happen?
Preterm birth occurs for a variety of reasons. While most
preterm births ‘just happen’ (spontaneously) some are due to
early induction of labour or a caesarean birth (which could be
for medical or non-medical reasons).
Common causes of preterm birth include multiple
pregnancies, infections and chronic conditions such as
diabetes and high blood pressure; however, often no cause is
identified. There can also be various genetic or social factors
that lead to preterm birth. A better understanding of these
causes and mechanisms will help health researchers to offer
new solutions to help prevent preterm birth.
Did you know?Fetal growth between 23 and 27 weeks is more rapid than at any other stage of human growth. This is the same period when extremely low birth-weight babies are born, i.e. below 1,000g — and that’s less than the weight of two blocks of butter!
What are we doing to help?
Here are just some of the research projects we are funding
to help improve preterm health in New Zealand.
Seeking a new treatment to prevent lung disease in extremely preterm babies
There are around 500 babies born extremely premature in New
Zealand every year and over 50% of these babies will develop
bronchopulmonary dysplasia (BPD) — a lung disease that
increases the risk of many other medical serious conditions.
But researchers led by Dr Chis McKinlay from Auckland
University are working on a new treatment to help premature
babies — and their families — breathe a little easier. Along
with neonatal specialists from around New Zealand and
Australia, Dr McKinlay has been investigating a new way of
giving anti-inflammatory steroids (corticosteroids) to babies
to help prevent the development of BPD.
Impact of preterm baby nutritional support on neurodevelopment
Babies born at moderate to late preterm (32 weeks to less than
37 weeks) account for more than 80% of all preterm births and
are at increased risk of adverse neurodevelopmental outcomes.
They’re also at risk of adverse long-term health outcomes such
as cardiovascular disease, obesity, and diabetes.
Nutrition in preterm babies is critical for supporting healthy
growth, including brain growth. But there is little evidence
to guide ‘optimal nutritional’ and practices varies widely.
Professor Frank Bloomfield’s trial is investigating the effects
of different feeding strategies in the early days after birth
until four months corrected age. The trial will enable the
research team to develop evidence-based nutritional support
Measuring the effect on babies (at age 2) treated with dextrose gel at birth.
Hypoglycaemia (low blood sugar) is the only readily
preventable cause of brain damage in newborn babies.
While up to 15% of newborn babies have low blood sugar,
this number is higher when the mother has diabetes
(50%) or the baby is born preterm (60%).
Professor Jane Harding is a neonatologist specialising in
the care of newborn babies. Her team (recent winners of the
Prime Minister’s Science Prize) have conducted a world-first trial which showed that dextrose gel massaged into the
inside of a baby’s cheek can be used to treat hypoglycemia
and therefore reduce the need for admission to intensive
care for treatment.
Improving the nutritional care of preterm babies
Researchers know that extremely preterm births
or extremely low birthweights can be considered a nutritional
emergency. So adequate protein intake in the weeks after
birth is critical for optimum growth and development, but
there is little evidence on the amount required.
Led by Dr Barbara Cormack and Professor Frank Bloomfield
the ProVIDe Study aims to assess whether a higher protein
intake in the week after birth will improve neurodevelopment
and the amount required.
Born at 29 weeks and 5 days, Jeremy is one of the approximately 700 babies born preterm each year.
When Jeremy arrived much earlier than expected, his parents and family were naturally very anxious about their little one and his future.
Jeremy’s dad Franky, who moved to New Zealand from China when he was 17 shares:
"We’re fortunate to have access to such an amazing healthcare system here. Without the advances in technology and improvement in medical care for premature babies, I just can’t imagine what might have happened to Jeremy and other premature babies."
Today, Jeremy is at school and thriving.
4 Active Preterm Health projects
Studying lung mechanics and breathing effort during assisted ventilation in NICUAwarded $19,630Preterm Health
Nutritional support for preterm babies and neurodevelopmentAwarded $109,617Preterm Health
A new treatment for preventing lung disease in extremely preterm babiesAwarded $109,997Preterm Health
Intranasal immunomodulatory for preterm brain injuryAwarded $106,937Preterm Health
Help fund our big research.
Every cent helps, no matter how small.
We are currently supporting over $16 million of child health research projects.Learn more
Preterm Health4 Active projects$861.5K
Childhood Cancers4 Active projects$3.2M
Maternal and Infant Conditions5 Active projects$995.2K
Rheumatic Heart Disease1 Active project$3.2M
Childhood Development and Learning Difficulties8 Active projects$1.6M
Neurological and Neurodevelopmental Disorders2 Active projects$1.1M
Obesity, Growth Disorders & Nutrition5 Active projects$1.4M
Mental Illnesses and Disorders10 Active projects$2.9M
Oral and Dental Disease2 Active projects$151K
Genetic Conditions and Rare Disorders5 Active projects$1.5M
Respiratory Conditions3 Active projects$735.8K
Infectious Disease1 Active project$100K
Gastrointestinal Conditions1 Active project$450K